Chlorhexidine (EENT)

Class: Anti-infectives, Miscellaneous
Chemical Name: N,N″-Bis(4-chlorophenyl)-3,12-diimino- 2,4,11,13-tetraazatetradecanediimidamide di-d-gluconate
Molecular Formula: C₂₂H₃₀Cl₂N₁₀•2C₆H₁₂O₇
CAS Number: 18472-51-0
Brands: Paroex, Peridex, PerioChip, PerioGard

Medically reviewed by Drugs.com on Apr 6, 2022. Written by ASHP.

Introduction

Topical anti-infective; cationic bisbiguanide.

Uses for Chlorhexidine (EENT)

Gingivitis

Used as a mouthwash or oral rinse (topical oral solution) for treatment of gingivitis; used between dental visits as part of a professional program.

Periodontitis

Used subgingivally (extended-release insert) for treatment of adult periodontitis as an adjunct to scaling and root planing to reduce periodontal pocket depth; used as part of a periodontal maintenance program that includes good oral hygiene.

Prevention of Dental Caries

Has been used as a topical oral solution for prevention of dental plaque and dental caries† when conventional oral hygiene measures are difficult or impossible, such as in patients with fractured jaws, periodontal surgery, or orthodontic treatments and in patients with seizure disorders, rheumatoid arthritis, mental retardation, and cerebral palsy.

Mucositis and Other Oral Complications in Individuals with Altered Immunocompetence

Has been used as a topical oral solution to decrease incidence and severity of mucositis† and other oral complications† in patients with altered immunocompetence, including those undergoing bone marrow transplantation, radiation therapy, or chemotherapy.

Has been used as a topical oral solution as adjunct to surgical debridement, plaque removal, and systemic anti-infectives in treatment of linear gingival erythema†, necrotizing ulcerative gingivitis†, and necrotizing ulcerative periodontiti...