Chlorphen Mal, Pseudoeph HCl

Generic name: chlorpheniramine maleate and pseudoephedrine hydrochloride
Dosage form: solution / drops
Drug class:Upper respiratory combinations

Medically reviewed by Drugs.com. Last updated on Dec 22, 2021.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

Chlorphen Mal, Pseudoeph HCl Description

Chlorphen Mal/Pseudoeph HCl 0.8/9 mg Drops is an antihistaminic and decongestant drop for oral administration.

Each dropperful (1 mL) contains:
Chlorpheniramine Maleate, USP ..... 0.8 mg
Pseudoephedrine HCl, USP ..... 9 mg

Inactive Ingredients
Glycerin, Propylene Glycol, Sorbitol, Citric Acid, Sodium Citrate, Sodium Saccharin, Red #40, Cherry Flavor, Purified Water.

Chlorpheniramine maleate is an antihistamine having the chemical name, 2-[p-Chloro--[2-(dimethylamino)ethyl]benzyl]pyridine maleate(1:1), with the following structure:

Pseudoephedrine hydrochloride is a decongestant having the chemical name, (Benzenemethanol, -[1-(methylamino)ethyl]-,[S-(R*,R*)]-,hydrochloride) with the following structure:

Chlorphen Mal, Pseudoeph HCl - Clinical Pharmacology

Antihistaminic and decongestant actions.

Chlorpheniramine Maleate
Chlorpheniramine maleate is a histamine antagonist, specifically an H1-receptor-blocking agent belonging to the alkylamine class of antihistamines. Antihistamines compete with histamine for receptor sites on effector cells. Chlorpheniramine also has mild anticholinergic (drying) and sedative effects. Among the antihistaminic effects, it antagonizes the allergic response (vasodilatation, increased vascular permeability, increased mucus secretion) of nasal tissue.

Chlorpheniramine is well absorbed from the gastrointestinal tract, with peak plasma concentration reached in 2 to 6 hours in adults. Urinary excretion is the major route of elimination, mostly as products of biodegradation. The liver is assumed to be the main site of metabolic transformation.