Chlorphenylcaine Ear Drops
Generic name: phenylephrine hydrochloride, antipyrine, benzocaine
Dosage form: otic drops
Drug class:Otic anesthetics
Medically reviewed by Drugs.com. Last updated on Dec 22, 2021.
Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.
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DESCRIPTION:
ACTIVE INGREDIENTS:Phenylephrine HCl ..... 0.25%
Antipyrine ..... 5%
Benzocaine..... 5%
INACTIVE INGREDIENTS:
Propylene Glycol, Sodium Metabisulfite.
Chlorphenylcaine Otic Drops is an analgesic-decongestant ear drop. Phenylephrine HCl is a sympathomimetic amine with local vasoconstriction or decongestant action. It is chemically, (1) Benzenemethanol, 3-hydroxy-α-[(methylamino)methyl]-, hydrochloride (R)-. (2) (—)-m-Hydroxy-α-[methylamino)methyl] benzyl alcohol hydrochloride. It occurs as white crystals and is freely soluble in water and alcohol. Antipyrine is an analgesic with local anesthetic action. It is chemically 2, 3-dimethyl-1- phenyl-3-pyrazolin-5-one. Antipyrine appears as colorless crystals or white powder and is soluble in water and alcohol. Benzocaine is a local anesthetic. It is chemically ethyl p-aminobenzoate. It occurs as white crystals or white crystalline powder and is slightly soluble in water and soluble in organic solvents.
CLINICAL PHARMACOLOGY:
Topical application of phenylephrine produces vasoconstriction mainly by a direct effect on α-adrenergic receptors. Phenylephrine, after absorption, is metabolized in the liver and the intestine by the enzyme monoamine oxidase (MAO). The type, route and rate of excretion of metabolites have not been defined. Like other local anesthetics, benzocaine acts by blocking nerve conduction first in autonomic, then in sensory and finally in motor nerve fibers. Its effect appears to be due to decreased nerve cell membrane permeability to sodium ions or competition with calcium ions for membrane binding sites. A vasoconstrictor, such as phenylephrine is added to decrease the rate of absorption and prolong the duration of action of the anesthetics. Antipyrine is believed to have analgesic and local anesthetic effects on the nerve endings. After absorption, it is slowly metabolized in the liver by oxidation and conjugated with glucuronic acid and is excreted in urine mainly in the conjug
