Cholografin Meglumine
Generic name:Iodipamide Meglumine
Dosage form: injection, solution
Drug class:Ionic iodinated contrast media
Medically reviewed by Drugs.com. Last updated on Nov 22, 2021.
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Cholografin Meglumine Description
Cholografin Meglumine (lodipamide Meglumine Injection 52%) is a radiopaque contrast agent for rapid intravenous cholangiography and cholecystography supplied as a sterile, aqueous solution. Each mL provides 520 mg iodipamide meglumine; at manufacture, 3.2 mg sodium citrate buffer and 0.4 mg edetate disodium sequestering agent are added per mL. The pH has been adjusted between 6.5 and 7.7 with meglumine and iodipamide. Each mL of solution also contains approximately 0.91 mg (0.039 mEq) sodium [18.2 mg/20 mL] and 257 mg organically bound iodine (5.2 g/20 mL). At the time of manufacture, the air in the container is replaced by nitrogen.
The appearance of the solution may vary from essentially colorless to light amber. Solutions which have become substantially darker, however, should not be used.
Cholografin Meglumine - Clinical Pharmacology
Following intravenous administration of Cholografin Meglumine, iodipamide is carried to the liver where it is rapidly secreted. The contrast medium appears in the bile within 10 to 15 minutes after injection, thus permitting visualization of the hepatic and common bile ducts, even in cholecystectomized patients. The biliary ducts are readily visualized within about 25 minutes after administration, except in patients with impaired liver function. The gallbladder begins to fill within an hour after injection; maximum filling is reached after two to two and one-half hours. The contrast medium is finally eliminated in the feces without passing through the enterohepatic circulation, except for approximately 10 percent of the intravenously administered dose which is excreted through the kidneys.
The LD50 for intravenous administration of a 52% iodipamide meglumine solution in mice is 6.2 ± 0.3 mL/kg (equivalent to 3224 ± 156 mg iodipamide meglumine/kg).
