Chromitope
Generic name: sodium chromate, CR-51
Dosage form: injection, solution
Drug class:Diagnostic radiopharmaceuticals
Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.
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Chromitope Description
Chromitope Sodium (Sodium Chromate Cr 51 Injection USP) is a diagnostic radiopharmaceutical for intravenous administration. This agent provides radioactive chromium 51 in the form of sterile, nonpyrogenic aqueous solution of sodium chromate (Na251CrO4). The solution also contains 6 mg/mL benzyl alcohol as a preservative and sodium chloride for isotonicity; the pH has been adjusted to 7.5–8.5 with hydrochloric acid or sodium bicarbonate.
PHYSICAL CHARACTERISTICS
Chromium 51 decays by electron capture and gamma emission with a physical half-life of 27.7 days.1 The principal photon that is useful for detection and imaging studies is listed in Table 1.
| Principal Radiation Emission Data | ||
|---|---|---|
| Radiation | Mean % per Disintegration | Mean Energy (keV) |
| Gamma-1 | 9.83 | 320.1 |
External Radiation
The specific gamma ray constant for Cr 51 is 0.19 R/hour-millicurie at 1 cm. The first half-value layer is 0.20 cm lead (Pb). Values for the relative attenuation of the radiation emitted by the radionuclide that result from interposition of two thicknesses of Pb are shown in Table 2. To facilitate control of the radiation exposure from millicurie amounts of this radionuclide, the use of a 0.60 cm thickness of lead will attenuate the radiation emitted by a factor of about 10.
| Radiation Attenuation by Lead Shielding | |
|---|---|
| Shield Thickness MEDICAL DEPARTMENTS
Cardiology
Pediatrics
Diabetes Care
Pre-natal Care
Ultrasound Echocardiogram
| |
