Ciclesonide (EENT)

Class: Corticosteroids
Chemical Name: (11β,16α)-16,17-[[(R)-Cyclohexylmethylene] bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-pregna-1,4-diene-3,20-dione
Molecular Formula: C₃₂H₄₄O₇
CAS Number: 126544-47-6
Brands: Omnaris

Medically reviewed by Drugs.com on Jul 30, 2021. Written by ASHP.

Introduction

Synthetic, non-halogenated corticosteroid.

Uses for Ciclesonide (EENT)

Allergic Rhinitis

Symptomatic treatment of seasonal or perennial allergic rhinitis.

Generally provides symptomatic relief of rhinorrhea, nasal congestion, sneezing, and nasal itching.

Ciclesonide (EENT) Dosage and Administration

General

• For therapeutic effectiveness, use at regular intervals.

Administration

Intranasal Administration

Administer by nasal inhalation using a metered-dose spray pump.

Shake spray pump gently immediately prior to priming or use.

Prior to initial use, prime spray pump by actuating 8 times. Prime pump after a period of nonuse (i.e., ≥4 days) by actuating once or until a fine spray appears.

Clear nasal passages prior to administration.

Tilt the head slightly forward; insert spray tip into one nostril, keeping bottle upright. Point the tip away from the nasal septum.

Pump the drug into one nostril while holding the other nostril closed and concurrently inspiring through the nose. Repeat procedure for the other nostril.

Wipe applicator with a clean tissue after use.

To unblock nasal applicator, remove dust cap and gently pull upward to free applicator. Wash dust cap and applicator in warm water, dry, replace applicator on bottle, and reprime the pump.

Dosage

After initial priming, nasal spray pump delivers 50 mcg of ciclesonide per metered spray. Each bottle containing 12.5 g of ciclesonide nasal spray delivers 120 metered sprays, after which the correct amount of drug in each spray cannot be assured.

Symptomatic relief usually is evident within 24–48 hours after initiation of therapy; further symptomatic improvement may occur over 1–2 weeks in seasonal allergic rhinitis or 5 weeks in perennial allergic rhinitis.

Once symptoms are controlled, gradually reduce dosage to the lowest effective level.

Pediatric Patients

Seasonal Allergic Rhinitis

Intranasal Inhalation

Children ≥6 years of age: 100 mcg (2 sprays) in each nostril once daily (total dosage: 200 mcg daily).

Perennial Allergic Rhinitis

Intranasal Inhalation

Children ≥12 years of age: 100 mcg (2 sprays) in each nostril once daily (total dosage: 200 mcg daily).

Adults

Seasonal Allergic Rhinitis

Intranasal Inhalation

100 mcg (2 sprays) in each nostril once daily (total dosage: 200 mcg daily).

Perennial Allergic Rhinitis

Intranasal Inhalation

100 mcg (2 sprays) in each nostril once daily (total dosage: 200 mcg daily).

Prescribing Limits

Exceeding the maximum recommended daily dosage may only increase the risk of adverse systemic effects.

Pediatric Patients

S...