Claris Clarifying Wash

Generic name: sulfacetamide sodium and sulfur
Dosage form: topical emulsion

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(Sodium Sulfacetamide 10% and Sulfur 4%)

Rx only

Claris Clarifying Wash Description

Each mL of CLARIS™ CLARIFYING WASH contains 100 mg of Sodium Sulfacetamide and 40 mg of Sulfur in an emulsion base containing Butylated Hydroxytoluene, Cetyl Alcohol, Disodium EDTA, Disodium Oleamido MEA Sulfosuccinate, Fragrance, Glyceryl Stearate and PEG 100 Stearate, Magnesium Aluminum Silicate, Methyl Paraben, Propyl Paraben, Purified Water, Sodium Cocoyl Isethionate, Sodium Methyl Cocoyl Taurate, Sodium Thiosulfate, Stearyl Alcohol, Urea 10% and Xanthan Gum.

Sodium Sulfacetamide is a sulfonamide with antibacterial activity while sulfur acts as a keratolytic agent. Chemically, Sodium Sulfacetamide is N-{(4-aminophenyl)sulfony}-acetamide, monosodium salt, monohydrate.

The structural formula is:

Claris Clarifying Wash - Clinical Pharmacology

The most widely accepted mechanism of action of sulfonamides in the Woods-Fildes theory which is based on the fact that sulfonamides act as competitive antagonists to para-aminobenzoic acid (PABA), an essential component for bacterial growth. While absorption through intact skin has not been determined, Sodium Sulfacetamide is readily absorbed from the gastrointestinal tract when taken orally and excreted in the urine, largely unchanged. The biological half-life has variously been reported as 7 to 12.8 hours.

The exact mode of action of sulfur in the treatment of acne is unknown, but it has been reported that it inhibits the growth of Propionibacterium acnes and the formation of free fatty acids.

Indications and Usage for Claris Clarifying Wash

CLARIS™ CLARIFYING WASH is indicated in the topical control of acne vulgaris, acne rosacea and seborrheic dermatitis.

Contraindications

CLARIS™ CLARIFYING WASH is contraindicated for use by patients having known hypersensitivity to sulfonamides, sulfur or any other component of this preparation. CLARIS™ CLARIFYING WASH is not to be used by patients with kidney disease.

Warnings

Although rare, sensitivity to Sodium Sulfacetamide may occur. Therefo...