Clinda-Derm

Generic name:clindamycin phosphate
Dosage form: topical solution
Drug class:Topical acne agents

Medically reviewed by Drugs.com. Last updated on Dec 22, 2021.

Description

Clindamycin Phosphate C18H34ClN2O8PS

(MW = 504.96)

Clindamycin phosphate topical solution, for external use, contains clindamycin phosphate at a concentration equivalent to 10 mg clindamycin per milliliter in a hydroalcoholic solution. Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.

The chemical name for clindamycin phosphate is 7(S)-chloro-7-deoxylincomycin-2-phosphate.

Each mL contains clindamycin phosphate equivalent to 10 mg clindamycin. In addition, each mL contains isopropyl alcohol (51.5% v/v), propylene glycol, sodium hydroxide and purified water.

CLINICAL PHARMACOLOGY:

Although clindamycin phosphate is inactive in vitro, rapid in vivo hydrolysis converts this compound to the antibacterially active clindamycin.

Clindamycin has been shown to have in vitro activity against isolates of Propionibacterium acnes. This may account for its usefulness in acne.

Cross resistance has been demonstrated between clindamycin and lincomycin.

Antagonism has been demonstrated between clindamycin and erythromycin.

Following multiple topical applications of clindamycin phosphate at a concentration equivalent to 10 mg clindamycin per mL in an isopropyl alcohol and water solution, very low levels of clindamycin are present in the serum (0-3 ng/mL) and less than 0.2% of the dose is recovered in urine as clindamycin.

Clindamycin activity has been demonstrated in comedones from acne patients. Clindamycin in vitro inhibits all Propionibacterium acnes cultures tested (MICs 0.4 mcg/mL). Free fatty acids on the skin surface have been decreased from approximately 14% to 2% following application of clindamycin.

INDICATIONS AND USAGE:

Clinda-Derm is indicated in the treatment of acne vulgaris. In view of the potential for diarrhea, bloody diarrhea and pseudomembranous colitis, the physician should consider whet...