Clindamycin and Tretinoin Gel

Generic name: clindamycin phosphate and tretinoin
Dosage form: gel
Drug class:Topical acne agents

Medically reviewed by Drugs.com. Last updated on Feb 1, 2022.

Indications and Usage for Clindamycin and Tretinoin Gel

Clindamycin phosphate and tretinoin gel is indicated for the topical treatment of acne vulgaris in patients 12 years and older.

Clindamycin and Tretinoin Gel Dosage and Administration

Clindamycin phosphate and tretinoin gel should be applied once daily in the evening, gently rubbing the medication to lightly cover the entire affected area. Approximately a pea-sized amount will be needed for each application. Avoid the eyes, lips, and mucous membranes.

Clindamycin phosphate and tretinoin gel is not for oral, ophthalmic, or intravaginal use.

Dosage Forms and Strengths

Clindamycin phosphate and tretinoin gel, 1.2%/0.025%, containing clindamycin phosphate 1.2% and tretinoin 0.025%, is a yellow, opaque topical gel. Each gram of clindamycin phosphate and tretinoin gel, 1.2%/0.025% contains, as dispensed, 10 mg (1%) clindamycin as clindamycin phosphate, and 0.25 mg (0.025%) tretinoin solubilized in an aqueous-based gel.

Contraindications

Clindamycin phosphate and tretinoin gel is contraindicated in patients with regional enteritis, ulcerative colitis, or history of antibiotic-associated colitis.

Warnings and Precautions

Colitis

Systemic absorption of clindamycin has been demonstrated following topical use. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical clindamycin. If significant diarrhea occurs, clindamycin phosphate and tretinoin gel should be discontinued.

Severe colitis has occurred following oral or parenteral administration of clindamycin with an onset of up to several weeks following cessation of therapy. Antiperistaltic agents such as opiates and diphenoxylate with atropine may prolong and/or worsen severe colitis. Severe colitis ma...