Generic name: clobetasol propionate
Dosage form: cream
Drug class:Topical steroids
Medically reviewed by Drugs.com. Last updated on Nov 1, 2021.
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DESCRIPTION
Clobetasol Propionate Cream, USP 0.05% contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical dermatologic use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.
Chemically, clobetasol propionate is 21-chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna 1,4-diene-3,20-dione, 17-propionate and it has the following structural formula:
Clobetasol propionate has the molecular formula C 25H 32CIFO 5 and a molecular weight of 466.97. It is a white to cream-colored crystalline powder insoluble in water.
Clobetasol propionate cream contains clobetasol propionate 0.5 mg/g in a cream base of propylene glycol, glyceryl monostearate, cetostearyl alcohol, glyceryl stearate SE, PEG 100 stearate, white wax, chlorocresol, sodium citrate, citric acid, and purified water.
CLINICAL PHARMACOLOGY
Like other topical corticosteroids, clobetasol propionate has an
