Clofarabine Injection

Dosage form: injection
Drug class:Antimetabolites

Medically reviewed by Drugs.com. Last updated on Oct 1, 2020.

Indications and Usage for Clofarabine Injection

Clofarabine Injection is indicated for the treatment of pediatric patients 1 to 21 years old with relapsed or refractory acute lymphoblastic leukemia after at least two prior regimens. This indication is based upon response rate. There are no trials verifying an improvement in disease-related symptoms or increased survival with Clofarabine Injection.

Clofarabine Injection Dosage and Administration

Recommended Dosage

Administer the recommended pediatric dose of 52 mg/m2 as an intravenous infusion over 2 hours daily for 5 consecutive days.

• Repeat treatment cycles following recovery or return to baseline organ function, approximately every 2 to 6 weeks. Base dosage on the patient's body surface area (BSA), calculated using the actual height and weight before the start of each cycle. To prevent drug incompatibilities, do not administer other medications through the same intravenous line. Administer subsequent cycles no sooner than 14 days from the starting day of the previous cycle and provided the patient's ANC is ≥0.75 × 109/L.
• Provide supportive care, such as intravenous fluids, antihyperuricemic treatment, and alkalinize urine throughout the 5 days of Clofarabine Injection administration to reduce the effects of tumor lysis and other adverse reactions.
• Discontinue Clofarabine Injection if hypotension develops during the 5 days of administration.
• Monitor renal and hepatic function during the 5 days of Clofarabine Injection administration [see Warnings and Precautions (5.7, 5.8)].
• Monitor patients taking medications known to affect blood pressure. Monitor cardiac function during administration of Clofarabine Injection.

Recommended Dosage Reduction for Renal Impairment

• Reduce the dose by 50% in patients with creatinine clearance...