Colchicine and probenecid

Generic name: colchicine and probenecid [ KOL-chi-seen-and-pro-BEN-e-sid ]
Dosage form: oral tablet (0.5 mg-500 mg)
Drug class:Antigout agents

Medically reviewed by Drugs.com on Aug 25, 2021. Written by Cerner Multum.

What is colchicine and probenecid?

Colchicine alters the way your body responds to uric acid crystals. Too much uric acid in the body is what leads to the symptoms of gout (swelling and pain).

Probenecid reduces the amount of uric acid in your body by causing it to be passed in your urine.

Colchicine and probenecid is a combination medicine used to prevent gout attacks. This medication will not cure gout and it will not stop a gout attack that has already started.

Colchicine and probenecid may also be used for purposes not listed in this medication guide.

Warnings

This medication will not stop a gout attack that has already started. Your doctor may prescribe other medications to treat your gout. Take all of your gout medications as directed.

Before taking this medicine

This medication will not stop a gout attack that has already started. Your doctor may prescribe other medications to treat your gout. Take all of your gout medications as directed.

To make sure colchicine and probenecid is safe for you, tell your doctor if you have:

• heart disease;

• kidney disease or a history of kidney stones;

• liver disease;

• a blood disease;

• stomach problems such as an ulcer or severe intestinal disorder;

• if you drink large amounts of alcohol; or

• if you are receiving chemotherapy or radiation.

It is not known whether colchicine and probenecid will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether colchicine and probenecid passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Older adults may be more sensitive to the side effects of this medication.

How should I take colchicine and probenecid?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take colchicine and probenecid in larger or smaller amounts or for longer than recommended.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using colchicine and probenecid.

You may take this medicine with food or milk if it upsets your stomach. You may also use an antacid.

You may not notice the effects of this medicine right away. Your gout atta...