Colesevelam Oral Suspension

Generic name: colesevelam hydrochloride
Dosage form: powder, for oral suspension
Drug class:Bile acid sequestrants

Medically reviewed by Drugs.com. Last updated on Apr 1, 2022.

Indications and Usage for Colesevelam Oral Suspension

Primary Hyperlipidemia

Colesevelam hydrochloride for oral suspension is indicated as an adjunct to diet and exercise to reduce elevated low-density lipoprotein cholesterol (LDL-C) in adults with primary hyperlipidemia.

Colesevelam hydrochloride for oral suspension is indicated to reduce LDL-C levels in boys and postmenarchal girls, 10 to 17 years of age, with heterozygous familial hypercholesterolemia (HeFH) who are unable to reach LDL-C target levels despite an adequate trial of dietary therapy and lifestyle modification.

Limitations of Use

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Colesevelam hydrochloride for oral suspension should not be used for the treatment of type 1 diabetes or for the treatment of diabetic ketoacidosis.

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Colesevelam hydrochloride for oral suspension has not been studied in Fredrickson Type I, III, IV, and V dyslipidemias.

Colesevelam Oral Suspension Dosage and Administration

Testing Prior to Initiation of Colesevelam Hydrochloride for Oral Suspension

Obtain lipid parameters, including triglyceride (TG) levels, before starting colesevelam hydrochloride for oral suspension. Colesevelam hydrochloride for oral suspension is contraindicated in patients with TG levels >500 mg/dL [see Contraindications (4) and Warnings and Precautions (5.1)].

Recommended Dosage in Primary Hyperlipidemia

The recommended dosage of colesevelam hydrochloride for oral suspension for adults and for boys and postmenarchal girls aged 10 to 17 years with primary hyperlipidemia is 3.75 grams daily or one 1.875 grams packet twice daily. Colesevelam hydrochloride for oral suspension should be taken as follows:

For Oral Suspension