Collagenase clostridium histolyticum
Generic name: collagenase clostridium histolyticum [ KOL-a-JEN-ase-klos-TRID-ee-um-HIS-toe-LIT-ik-um ]
Brand name: Xiaflex
Dosage form: injectable powder for injection (0.9 mg)
Drug class:Miscellaneous uncategorized agents
What is collagenase clostridium histolyticum?
Collagenase clostridium histolyticum is made from a mixture of proteins derived from a certain bacteria.
Collagenase clostridium histolyticum is used to treat Dupuytren's contracture in adults. This condition causes an abnormal thickening of the tissue in the palm of the hand. This condition may get worse over time and form a "cord" in your palm, causing a permanent bend in your finger.
Collagenase clostridium histolyticum is also used to treat a related condition called Peyronie's disease in adult men. This condition causes scar tissue or "plaque" to develop under the skin of the penis, resulting in an abnormal curving of the penis during erection.
Collagenase clostridium histolyticum is available for Peyronie's disease only from a certified pharmacy under a special program called Xiaflex REMS. You must be registered in the program and understand the risks of taking collagenase clostridium histolyticum.
Collagenase clostridium histolyticum may also be used for purposes not listed in this medication guide.
Warnings
Collagenase clostridium histolyticum can damage a nerve, tendon, or ligament in the hand the medicine is injected into. After the swelling from your injection goes down, call your doctor if you have numbness, tingling, increased pain, trouble bending your finger toward your wrist, or if you have new or worsened movement problems in your treated hand.
This medicine may also damage the erectile tissues inside a man's penis, which could require surgery to correct. Call your doctor right away if you have bruising and swelling of your penis, pain when you urinate, blood in the urine, sudden erection problems, or a "popping" sound or sensation in your penis during an erection.
Before taking this medicine
You should not use collagenase clostridium histolyticum if you are allergic to it. collagenase clostridium histolyticum should not be used to treat Peyronie's disease that affects the urethra (the tube for passing urine out of your bladder).
To make sure collagenase clostridium histolyticum is safe for you, tell your doctor if you have:
a bleeding or blood clotting disorder, such as hemophilia; or
if you take a blood thinner such as
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CardiologyPediatricsDiabetes CarePre-natal CareUltrasound Echocardiogram
