Complement C1 esterase inhibitor
Generic name: complement C1 esterase inhibitor [ KOM-ple-ment-C1 ES-ter-ase-in-HIB-it-or ]
Brand names: Berinert, Cinryze, Haegarda
Dosage forms: intravenous kit (500 intl units); intravenous powder for injection (500 units); subcutaneous powder for injection (2000 intl units; 3000 intl units)
Drug class:Hereditary angioedema agents
What is complement C1 esterase inhibitor?
Complement C1 esterase inhibitor is a man-made form of a protein in blood that helps control swelling in the body. People with a condition called hereditary angioedema do not have enough of this protein. Hereditary angioedema can cause attacks of swelling and symptoms such as stomach problems or trouble breathing.
Complement C1 esterase inhibitor is used in people with hereditary angioedema. Berinert is used to treat attacks of angioedema. Cinryze and Haegarda are used to prevent attacks of angioedema.
Complement C1 esterase inhibitor may also be used for purposes not listed in this medication guide.
Warnings
You should not use complement C1 esterase inhibitor if have ever had a life-threatening allergic reaction to complement C1 esterase inhibitor.
Before taking this medicine
You should not use this medicine if have ever had a life-threatening allergic reaction to complement C1 esterase inhibitor.
Tell your doctor if you have ever had:
a stroke or blood clot;
heart problems; or
an "in-dwelling" catheter.
Tell your doctor if you are pregnant or breast-feeding.
Complement C1 esterase inhibitor is made from donated human plasma and may contain viruses or other infectious agents. Donated plasma is tested and treated to reduce the risk of contamination, but there is still a small possibility it could transmit disease. Ask your doctor about any possible risk.
How should I use complement C1 esterase inhibitor?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Cinryze or Berinert are given as an infusion into a vein. Haegarda is injected under the skin. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.
Read and carefully follow any Instructions for Use provided with your medicine. Prepare an injection only when you are ready to give it. Ask your doctor or pharmacist if you don't understand all instructions.
Seek emergency medical attention after using Berinert to treat an angioedema attack.
Storing unopened vials: Store in a refrigerator ...
