Conivaptan (Intravenous)

Medically reviewed by Drugs.com. Last updated on Jan 14, 2022.

Commonly used brand name(s)

In the U.S.

• Vaprisol

Available Dosage Forms:

• Solution

Therapeutic Class: Endocrine-Metabolic Agent

Pharmacologic Class: Vasopressin Receptor Antagonist, V1a/V2

Uses for conivaptan

Conivaptan injection is used to treat euvolemic hyponatremia (a condition where there is not enough sodium in your blood but with a normal blood volume). Sodium is a chemical that the body needs to be able to function well. Even if there is a normal blood volume, but with a low sodium level, it can still be a danger to your health. Conivaptan works by maintaining the right amount of sodium that the body needs.

Conivaptan is to be given only by or under the supervision of your doctor.

Before using conivaptan

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For conivaptan, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to conivaptan or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of conivaptan injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of conivaptan injection in the elderly.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving conivaptan, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using conivaptan with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Alfuzosin
• Alprazolam
• Boceprevir
• Clarithromycin
• Cobicistat
• Colchicine
• Delavirdine
• Dronedarone
• Eletriptan
• Eliglustat
• Eplerenone
• Ergotamine
• Finerenone
• Flibanserin
• Idelalisib
• Indinavir
• Isavuconazonium Sulfate
• Itraconazole
• Ivabradine
• Ketoconazole
• Levoketoconazole
• Lomitapide
• Lopinavir
• Lurasidone
• Maraviroc
• Mavacamten
• Naloxegol
• Nefazodone
• Nelfinavir
• Nimodipine
• Pacritinib
...