Copper

Generic name: cupric chloride
Dosage form: injection, solution
Drug class:Minerals and electrolytes

Medically reviewed by Drugs.com. Last updated on Apr 1, 2021.

Cupric Chloride

Injection, USP

FOR I.V. USE ONLY AFTER DILUTION

Plastic Vial

Rx only

Copper Description

Copper 0.4 mg/mL (Cupric Chloride Injection, USP) is a sterile, nonpyrogenic solution intended for use as an additive to intravenous solutions for total parenteral nutrition (TPN). Each mL of solution contains 1.07 mg cupric chloride, dihydrate and 9 mg sodium chloride.

The solution contains no bacteriostat, antimicrobial agent or added buffer. The pH is 2.0 (1.5 to 2.5); product may contain hydrochloric acid and sodium hydroxide for pH adjustment. The osmolarity is 0.327 mOsmol/mL (calc.).

Cupric chloride, USP is chemically designated cupric chloride, dihydrate (CuCl2• 2H2O), a crystalline compound freely soluble in water.

Sodium Chloride, USP is chemically designated NaCl, a white crystalline compound freely soluble in water.

The semi-rigid vial is fabricated from a specially formulated polyolefin. It is a copolymer of ethylene and propylene. The safety of the plastic has been confirmed by tests in animals according to USP biological standards for plastic containers. The small amount of water vapor that can pass through the plastic container wall will not significantly alter the drug concentration.

Copper - Clinical Pharmacology

Copper is an essential nutrient which serves as a cofactor for serum ceruloplasmin, an oxidase necessary for proper formation of the iron carrier protein, transferrin. Copper also helps maintain normal rates of red and white blood cell formation.

Providing Copper during TPN helps prevent development of the following deficiency symptoms: Leukopenia, neutropenia, anemia, depressed ceruloplasmin levels, impaired transferrin formation, secondary iron deficiency and osteoporosis.

Normal serum Copper values range from 80 to 163 mcg/dl (mean, approximately 110 mcg/dl). The serum Copper level at which deficiency symptoms appear is not precisely defined. A serum value of 9 mcg Copper/dl was reported for one TPN patient who received no Copper. The daily turnover of Coppe...