Ablysinol

Generic name:dehydrated alcohol
Dosage form: injection, solution
Drug class:Miscellaneous uncategorized agents

Medically reviewed by Drugs.com. Last updated on Dec 1, 2021.

Indications and Usage for Ablysinol

Ablysinol ® is indicated to induce controlled cardiac septal infarction to improve exercise capacity in adults with symptomatic hypertrophic obstructive cardiomyopathy who are not candidates for surgical myectomy.

Ablysinol Dosage and Administration

Recommended Dosing

Use the minimum dose necessary to achieve the desired reduction in peak left ventricular outflow tract pressure gradient. Inject small volumes over 1 to 2 minutes percutaneously into septal arterial branches, guided by assessment of the gradient. In most situations, a dose of 1 mL to 2 mL is sufficient. The maximum dose of Ablysinol that should be used in a single procedure is 5 mL.

Administration

Ablysinol should only be administered under the supervision of a qualified interventional cardiologist experienced in the percutaneous transluminal septal myocardial ablation procedure.

Inspect visually for particulate matter and discoloration prior to administration. Ablysinol should appear as a clear, colorless solution.

Dosage Forms and Strengths

Injection: 1 mL or 5 mL of ethyl alcohol ≥ 99% by volume as a clear, colorless liquid in a single-dose glass ampule.

Contraindications

None.

Warnings and Precautions

Heart Block

Transient Heart Block
Transient heart block is common at the time of dehydrated alcohol, such as Ablysinol, injection into a septal artery. Prior to the injection, a temporary pacing wire is routinely inserted into the apex of the right ventricle, usually vi..