Class: Anti-inflammatory Agents, Miscellaneous
VA Class: IM600
Chemical Name: Cyclo[[(E)-(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl]-l-2-aminobutyryl-N-methylglycyl-N-methyl-l-leucyl-l-valyl-N-methyl-l-leucyl-l-alanyl-d-alanyl-N-methyl-l-leucyl-N-methyl-l-leucyl-N-methyl-l-valyl]
CAS Number: 59865-13-3
Brands: Restasis
Introduction
Topical immunomodulator; systemic immunosuppressive agent.
Uses for cycloSPORINE (EENT)
Keratoconjunctivitis Sicca
Used to increase tear production in adults whose tear production presumably is suppressed secondary to ocular inflammation related to keratoconjunctivitis sicca.
Increased tear production not observed in patients already receiving topical anti-inflammatory agents or using punctal plugs.
cycloSPORINE (EENT) Dosage and Administration
Administration
For ophthalmic use only. Not for injection. Not for subconjunctival injection or introduction directly into the anterior chamber of the eye.
Ophthalmic Administration
Apply topically to the eye as an ophthalmic emulsion.
Avoid contamination of emulsion container.
Invert unit-dose vial a few times before use to obtain a uniform, opaque, white emulsion.
Preservative-free emulsion is for single use only in one or both eyes; discard any unused portion immediately after administration.
Remove contact lenses prior to administration; may reinsert lenses 15 minutes after dose.
When used concomitantly with artificial tears, administer ophthalmic preparations at least 15 minutes apart.
Dosage
Adults
Keratoconjunctivitis Sicca
Ophthalmic
1 drop of a 0.05% emulsion into each eye twice daily, approximately 12 hours apart.