Daunorubicin citrate liposome (Intravenous)
Medically reviewed by Drugs.com. Last updated on Apr 8, 2022.
Cardiac function should be monitored regularly because of the potential risk for cardiac toxicity and congestive heart failure. Cardiac monitoring is advised, especially in those patients who received prior anthracyclines, have preexisting cardiac disease, or had prior radiotherapy encompassing the heart. Severe myelosuppression may occur and dosage should be reduced in patients with impaired hepatic function. A triad of back pain, flushing, and chest tightness has been reported that generally occurs during the first 5 minutes of the infusion, subsides with interruption of the infusion, and does not recur if the infusion is then resumed at a slower rate .
Commonly used brand name(s)
In the U.S.
- Daunoxome
Chemical Class: Anthracycline
Uses for daunorubicin citrate liposome
Liposomal daunorubicin belongs to the general group of medicines known as antineoplastics. It is used to treat advanced acquired immunodeficiency syndrome (AIDS)–associated Kaposi's sarcoma (KS), a kind of skin cancer.
Liposomal daunorubicin seems to interfere with the growth of cancer cells, which eventually are destroyed. Since the growth of normal body cells also may be affected by liposomal daunorubicin, other effects will occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur until months or years after the medicine is used.
Before you begin treatment with liposomal daunorubicin, you and your doctor should talk about the good daunorubicin citrate liposome will do as well as the risks of using it.
Liposomal daunorubicin is to be administered only by or under the immediate supervision of your doctor.
Before using daunorubicin citrate liposome
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For daunorubicin citrate liposome, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to daunorubicin citrate liposome or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
There is no specific information comparing the use of liposomal daunorubicin in children with use in any other age group. Safety and efficacy of liposomal daunorubicin in children have not been established.
Geriatric
There is no specific information comparing the use of liposomal daunorubicin in the elderly with use in any other age group. Safety and efficacy of liposomal daunorubicin in the elderly have not been established.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even ..
