Defibrotide (Intravenous)
Medically reviewed by Drugs.com. Last updated on Apr 25, 2022.
Commonly used brand name(s)
In the U.S.
- Defitelio
Available Dosage Forms:
- Solution
Uses for defibrotide
Defibrotide injection is used to treat hepatic veno-occlusive disease in adults and children with kidney or lung problems who received hematopoietic stem-cell transplantation (HSCT).
Defibrotide is to be given by or under the supervision of your doctor.
Before using defibrotide
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For defibrotide, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to defibrotide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of defibrotide injection in children.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of defibrotide injection in the elderly.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving defibrotide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using defibrotide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Abciximab
- Acenocoumarol
- Alteplase, Recombinant
- Anagrelide
- Anistreplase
- Apixaban
- Ardeparin
- Argatroban
- Aspirin
- Bemiparin
- Bivalirudin
- Certoparin
- Cilostazol
- Clopidogrel
- Dabigatran Etexilate
- Dalteparin
- Danaparoid
- Desirudin
- Dipyridamole
- Edoxaban
- Enoxaparin
- Eptifibatide
- Fondaparinux
- Heparin
- Iloprost
- Lepirudin
- Nadroparin
- Parnaparin
- Phenindione
- Phenprocoumon
- Prasugrel
- Protein C
- Reteplase, Recombinant
- Reviparin
- Rivaroxaban
- Streptokinase
- Sulfinpyrazone
- Tenecteplase
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tirofiban
- Treprostinil
- Urokinase
- Vorapaxar
- Warfarin
Using defibrotide with any of the following medicines is usually ...
