Dengue Vaccine Live
Class: Vaccines
Brands: Dengvaxia
Introduction
Dengue vaccine live is a live, attenuated virus vaccine.
Uses for Dengue Vaccine Live
Dengue vaccine live has the following uses:
Dengue vaccine live is a vaccine indicated for the prevention of dengue disease caused by dengue virus serotypes 1, 2, 3 and 4. Dengue vaccine live is approved for use in individuals 9 through 16 years of age with laboratory-confirmed previous dengue infection and living in endemic areas.
Dengue vaccine live has the following limitations of use:
Dengue vaccine live is not approved for use in individuals not previously infected by any dengue virus serotype or for whom this information is unknown. Those not previously infected are at increased risk for severe dengue disease when vaccinated and subsequently infected with dengue virus. Previous dengue infection can be assessed through a medical record of a previous laboratory-confirmed dengue infection or through serological testing prior to vaccination.
The safety and effectiveness of dengue vaccine live have not been established in individuals living in dengue nonendemic areas who travel to dengue endemic areas.
Dengue Vaccine Live Dosage and Administration
General
Dengue vaccine live is available in the following dosage form(s) and strength(s):
Suspension for injection (0.5 mL) supplied as a lyophilized powder to be reconstituted with the supplied diluent.
Dosage
It isessentialthat the manufacturer's labeling be consulted for more detailed information on dosage and administration of this drug. Dosage summary:
Pediatric Patients
Three doses (0.5 mL each) 6 months apart (at month 0, 6, and 12).
Cautions for Dengue Vaccine Live
Contraindications
A history of severe allergic reaction to a previous dose of dengue vaccine live or to any component of dengue vaccine live.
Immunocompromised individuals.
Warnings/Precautions
Increased Risk of Severe Dengue Disease Following Dengue Vaccine Live in Persons Not Previously Infected with Dengue Virus
In unvaccinated individuals, first dengue infections rarely cause severe dengue disease, while second dengue infections with a different serotype are associated with an increased risk of severe dengue disease. Dengue vaccine live administration to individuals not previously infected by dengue virus is associated with an increased risk of severe dengue disease when the vaccinated individual is subsequently infected w...
