Agalsidase beta
Generic name: agalsidase beta [ a-GAL-sih-daze-BAY-tah ]
Brand name: Fabrazyme
Dosage form: intravenous powder for injection (35 mg; 5 mg)
Drug class:Lysosomal enzymes
What is agalsidase beta?
Agalsidase beta is used in the treatment of Fabry disease (a deficiency of alpha-galactosidase A enzyme) in adults and children at least 2 years old.
Agalsidase beta may also be used for purposes other than those listed here.
Warnings
Many people have a severe reaction to agalsidase beta. Tell your caregiver if you have a skin rash or hives, fever, chills, headache, muscle pain, dizziness, numbness, swelling, vomiting, diarrhea, chest pain, trouble swallowing or breathing, fast or slow heart rate, or severe dizziness.
Before taking this medicine
Tell your doctor if you have ever had:
heart problems; or
an allergic reaction to agalsidase beta or have antibodies to the medication.
Tell your doctor if you are pregnant or breastfeeding.
Your name may be listed on a Fabry disease patient registry. This is to track the progress of your disease and to evaluate the treatment effects of agalsidase beta. Taking part in this registry is especially important if you are pregnant or breast-feeding.
How should I use agalsidase beta?
Agalsidase beta is injected into a vein by a healthcare provider, usually given once every 2 weeks.
Doses are based on weight. Your dose may change if you gain or lose weight.
You may need frequent medical tests.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your injection.
What happens if I overdose?
In a medical setting an overdose would be treated quickly.
What should I avoid while receiving agalsidase beta?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Agalsidase beta side effects
Get emergency medical help if you have signs of an allergic reaction:
wheezing, chest tightness, trouble breathing, feeling light-headed;
skin rash, hives, flushing (warmth, redness, or tingly feeling);
trouble swallowing; or
swelling of your face, lips, tongue, or throat.
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