Desoximetasone

Class: Corticosteroids
ATC Class: D07AC03
VA Class: DE200
Chemical Name: Pregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16-methyl-,(11ß,16α)-
Molecular Formula: C₂₂H₂₉FO₄
CAS Number: 382-67-2
Brands: Topicort

Medically reviewed by Drugs.com on Jan 19, 2022. Written by ASHP.

Introduction

A synthetic fluorinated corticosteroid.

Uses for Desoximetasone

Corticosteroid-responsive Dermatoses

Relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Generally most effective in acute or chronic dermatoses (e.g., seborrheic or atopic dermatitis, localized neurodermatitis, anogenital pruritus, psoriasis, late phase of allergic contact dermatitis, inflammatory phase of xerosis).

Topical therapy generally preferred over systemic therapy; fewer associated adverse systemic effects.

Topical therapy generally only controls manifestations of dermatoses; eliminate cause if possible.

Topical efficacy may be increased by using a higher concentration or occlusive dressing therapy. (See Administration with Occlusive Dressing under Dosage and Administration.)

Response may vary from one topical corticosteroid preparation to another.

Anti-inflammatory activity may vary considerably depending on the vehicle, drug concentration, site of application, disease, and individual patient.

Desoximetasone cream, ointment, and gel are considered to have high-range potency.

Desoximetasone Dosage and Administration

General

• Consider location of the lesion and condition being treated when choosing a dosage form.

• Creams are suitable for most dermatoses, but ointments may also provide some occlusion and are usually used for the treatment of dry, scaly lesions. Gels may be used on hairy areas, particularly the scalp.

• Formulation affects percutaneous penetration and subsequent activity; extemporaneous preparation or dilution of commercially ...