Dexrazoxane
Generic name: dexrazoxane [ dex-ray-ZOX-ane ]
Brand names: Totect, Zinecard
Dosage form: intravenous powder for injection (250 mg; 500 mg)
Drug class:Miscellaneous uncategorized agents
What is dexrazoxane?
Dexrazoxane is used to protect the heart and other tissues from harmful side effects caused by certain cancer medications.
The Totect brand of dexrazoxane is used in men or women to treat a condition called extravasation (es-TRA-va-ZAY-shun). Extravasation happens when an injected medicine escapes from the blood vessels and circulates into tissues in the body. Serious tissue damage can occur when extravasation happens during injection of certain cancer medications.
Dexrazoxane is also used to help prevent chemotherapy-related heart problems in women who are receiving doxorubicin for metastatic breast cancer. dexrazoxane is given only after you have received enough doxorubicin infusions to amount to a certain total dose.
Dexrazoxane may also be used for purposes not listed in this medication guide.
Warnings
Dexrazoxane can harm an unborn baby or cause birth defects if the mother or father is using this medicine. Tell your caregivers if you are pregnant, or if you are a man and your sex partner is able to get pregnant.
You should not receive Zinecard if your chemotherapy does not include doxorubicin or a similar medication (such as daunorubicin, epirubicin, idarubicin, or mitoxantrone).
Tell your doctor at once if you have signs of infection such as fever, chills, sore throat, easy bruising or bleeding, skin sores, or warmth and redness of any surgical incision.
Before taking this medicine
You should not receive Zinecard if your chemotherapy does not include doxorubicin or a similar medication such as:
daunorubicin (Cerubidine, Daunoxome);
epirubicin (Ellence);
idarubicin (Idamycin); or
mitoxantrone (Novantrone).
Tell your doctor if you have ever had:
heart problems;
liver disease; or
kidney disease.
Dexrazoxane can harm an unborn baby or cause birth defects if the mother or the father is receiving dexrazoxane. Women should use effective birth control to prevent pregnancy while receiving dexrazoxane and for at least 6 months after the last dose. Men should use birth control during treatment and for at least 3 months after the last dose. Tell your doctor right away if a pregna...
