Generic name:adapalene
Dosage form: gel
Drug class:Topical acne agents
Medically reviewed by Drugs.com. Last updated on May 23, 2022.
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DESCRIPTION:
DIFFERIN® Gel, containing adapalene, is used for the topical treatment of acne vulgaris. Each gram of Differin Gel contains adapalene 0.1% (1 mg) in a vehicle consisting of carbomer 940, edetate disodium, methylparaben, poloxamer 182, propylene glycol, purified water and sodium hydroxide. May contain hydrochloric acid to adjust pH.
The chemical name of adapalene is 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid. Adapalene is a white to off-white powder which is soluble in tetrahydrofuran, sparingly soluble in ethanol, and practically insoluble in water. The molecular formula is C28H28O3 and molecular weight is 412.52. Adapalene is represented by the following structural formula:
CLINICAL PHARMACOLOGY:
Adapalene is a chemically stable, retinoid-like compound. Biochemical and pharmacological profile studies have demons...
