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Diphenhydramine and ibuprofen
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Diphenhydramine and ibuprofen

Generic name: diphenhydramine and ibuprofen [ DYE-fen-HYE-dra-meen-and-EYE-bue-proe-fen ]
Brand names: Advil PM, Advil PM Liqui-Gels, Ibuprofen PM, Motrin PM
Dosage forms: oral capsule (25 mg-200 mg); oral tablet (38 mg-200 mg)
Drug class:Analgesic combinations

Medically reviewed by Drugs.com on Nov 3, 2020. Written by Cerner Multum.

What is diphenhydramine and ibuprofen?

Diphenhydramine is an antihistamine. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID).

Diphenhydramine and ibuprofen is a combination medicine used to treat occasional insomnia associated with minor aches and pains. diphenhydramine and ibuprofen is not for use in treating sleeplessness without pain, or sleep problems that occur often.

Diphenhydramine and ibuprofen is for use in adults and children at least 12 years old.

Diphenhydramine and ibuprofen may also be used for purposes not listed in this medication guide.

Warnings

Ibuprofen can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal.

Use this medicine exactly as directed. Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.

Before taking this medicine

Ibuprofen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use diphenhydramine and ibuprofen just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using diphenhydramine and ibuprofen, especially in older adults.

You should not use this medicine if you are allergic to diphenhydramine or ibuprofen, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had: