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Diphenhydramine and naproxen
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Diphenhydramine and naproxen

Generic name: diphenhydramine and naproxen [ DYE-fen-HYE-dra-meen-and-na-PROX-en ]
Brand name: Aleve PM
Dosage form: oral tablet (25 mg-220 mg)
Drug class:Analgesic combinations

Medically reviewed by Drugs.com on Dec 18, 2020. Written by Cerner Multum.

What is diphenhydramine and naproxen?

Diphenhydramine is an antihistamine. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID).

Diphenhydramine and naproxen is a combination medicine used to treat occasional insomnia associated with minor aches and pains. diphenhydramine and naproxen is not for use in treating sleeplessness without pain, or sleep problems that occur often.

Diphenhydramine and naproxen is for use in adults and children at least 12 years old.

Diphenhydramine and naproxen may also be used for purposes not listed in this medication guide.

Warnings

Naproxen can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Naproxen may also cause stomach or intestinal bleeding, which can be fatal.

Use this medicine exactly as directed. Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.

Before taking this medicine

Naproxen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use diphenhydramine and naproxen just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Naproxen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using diphenhydramine and naproxen, especially in older adults.

You should not use this medicine if you are allergic to diphenhydramine or naproxen, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had: