Diphenhydramine and phenylephrine

Generic name: diphenhydramine and phenylephrine [ DYE-fen-HYE-dra-meen-and-FEN-il-EFF-rin ]
Brand names: Children's Triacting Night Time, Dimetapp Nighttime Cold and Congestion, Dytan-D, Triaminic Night Time Cold and Cough, Diphentann-D, ... show all 19 brands D-Tann, Uni-Tann D, Aldex-CT, Diphenmax D, Alahist LQ, Robitussin Night Time Cough and Cold, Robitussin Night Time Cough and Cold Pediatric, PediaCare Children's Allergy and Cold, Robitussin Night Time Cough and Cold Children's, Zoden PD, Benadryl-D Children's Allergy and Sinus, Delsym Children's Night Time Cough and Cold, Children's Allergy Plus Congestion, Benadryl Allergy Plus Congestion
Dosage forms: oral liquid (12.5 mg-5 mg/5 mL; 6.25 mg-2.5 mg/5 mL); oral suspension, extended release (25 mg-7.5 mg/5 mL); oral tablet (25 mg-10 mg)
Drug class:Upper respiratory combinations

Medically reviewed by Drugs.com on Apr 27, 2022. Written by Cerner Multum.

What is diphenhydramine and phenylephrine?

Diphenhydramine is an antihistamine. Phenylephrine is a decongestant.

Diphenhydramine and phenylephrine is a combination medicine used to treat runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

Diphenhydramine and phenylephrine may also be used for purposes not listed in this medication guide.

Warnings

Do not use diphenhydramine and phenylephrine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine, and others.

Use diphenhydramine and phenylephrine exactly as directed. Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.

Do not use this medicine to make a child sleepy. Ask a doctor before giving the medicine to a child younger than 6 years old.

Ask a doctor or pharmacist before using any other medicine that may contain diphen