Dolutegravir and rilpivirine

Generic name: dolutegravir and rilpivirine [ DOE-loo-TEG-ra-vir-and-RIL-pi-VIR-een ]
Brand name: Juluca
Dosage form: oral tablet (50 mg-25 mg)
Drug class:Antiviral combinations

Medically reviewed by Drugs.com on Jul 20, 2020. Written by Cerner Multum.

What is dolutegravir and rilpivirine?

Dolutegravir and rilpivirine is a combination antiviral medicine used to treat HIV, the virus that can cause the acquired immunodeficiency syndrome (AIDS). dolutegravir and rilpivirine is not a cure for HIV or AIDS.

Dolutegravir and rilpivirine is for use only in people who have been successfully treated with other antiviral medications for at least 6 months.

Dolutegravir and rilpivirine may also be used for purposes not listed in this medication guide.

Warnings

Taking dolutegravir during the first trimester of pregnancy may cause birth defects. Use effective birth control to prevent pregnancy while you are using dolutegravir.

Before taking this medicine

You should not use dolutegravir and rilpivirine if you are allergic to dolutegravir or rilpivirine.

Some medicines can cause unwanted or dangerous effects when used with dolutegravir and rilpivirine. Your doctor may change your treatment plan if you also use:

• dofetilide (can cause serious medical problems or death when taken with dolutegravir and rilpivirine);

• St John's wort;

• more than one dose of dexamethasone;

• carbamazepine, oxcarbazepine, phenobarbital, phenytoin;

• rifampin, rifapentine; or

• esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole.

Tell your doctor if you have ever had:

• liver problems;

• mental illness;

• a severe skin rash or allergic reaction to dolutegravir or rilpivirine; or

• if you also take rifabutin.

You may need to have a negative pregnancy test before starting this treatment.

Dolutegravir and rilpivirine may harm an unborn baby if you take the medicine at the time of conception or during the...