#
Donepezil and memantine
  • Treatments
  • Alzheimer's Disease

Donepezil and memantine

Generic name: donepezil and memantine [ doe-NEP-e-zil-and-mem-AN-teen ]
Brand names: Namzaric, Namzaric Titration Pack
Dosage form: oral capsule, extended release (10 mg-14 mg; 10 mg-21 mg; 10 mg-28 mg)
Drug class:Cholinesterase inhibitors

Medically reviewed by Drugs.com on Nov 1, 2021. Written by Cerner Multum.

What is donepezil and memantine?

Donepezil improves the function of nerve cells in the brain. It works by preventing the breakdown of a chemical called acetylcholine (ah SEET il KOE leen). People with dementia usually have lower levels of this chemical, which is important for the processes of memory, thinking, and reasoning.

Memantine reduces the actions of chemicals in the brain that may contribute to the symptoms of Alzheimer's disease.

Donepezil and memantine is a combination medicine used to treat moderate to severe dementia of the Alzheimer's type.

Donepezil and memantine is not a cure for Alzheimer's disease. This condition will progress over time, even in people who take donepezil.

Donepezil and memantine may also be used for purposes not listed in this medication guide.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use donepezil and memantine if you are allergic to donepezil or memantine.

To make sure donepezil and memantine is safe for you, tell your doctor if you have:

  • asthma or other breathing disorder;

  • heart disease, or heart rhythm disorder;

  • a history of seizures;

  • stomach ulcer, or a history of stomach or intestinal bleeding;

  • bladder obstruction or other urination problems;

  • liver disease; or

  • kidney disease.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether donepezil and memantine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take donepezil and memantine?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine at bedtime unless your doctor tells you otherwise.

You may take donepezil a...