Dorzolamide and Timolol Ophthalmic Solution

Generic name: dorzolamide hydrochloride and timolol maleate
Dosage form: ophthalmic solution
Drug class:Ophthalmic glaucoma agents

Medically reviewed by Drugs.com. Last updated on Jan 1, 2022.

Indications and Usage for Dorzolamide and Timolol Ophthalmic Solution

Dorzolamide hydrochloride and timolol maleate ophthalmic solution preservative free is indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers (failed to achieve target IOP determined after multiple measurements over time). The IOP-lowering of dorzolamide hydrochloride and timolol maleate ophthalmic solution administered twice a day was slightly less than that seen with the concomitant administration of 0.5% timolol administered twice a day and 2% dorzolamide administered three times a day [see Clinical Studies (14.1)].

Dorzolamide and Timolol Ophthalmic Solution Dosage and Administration

The dose is one drop of dorzolamide hydrochloride and timolol maleate ophthalmic solution preservative free in the affected eye(s) two times daily.

If more than one topical ophthalmic drug is being used, the drugs should be administered at least five minutes apart [see Drug Interactions (7.3)].

The solution from one individual unit is to be used immediately after opening for administration to one or both eyes. Since sterility cannot be maintained after the individual unit is opened, the remaining contents should be discarded immediately after administration.

Dosage Forms and Strengths

Solution containing 20 mg/mL dorzolamide (22.26 mg of dorzolamide hydrochloride) and 5 mg/mL timolol (6.83 mg timolol maleate).

Contraindications

Asthma, COPD

Dorzolamide hydrochloride and timolol maleate ophthalmic solution preservative free i...