Doxercalciferol Injection

Dosage form: injection, solution
Drug class:Vitamins

Medically reviewed by Drugs.com. Last updated on Jan 1, 2022.

Indications and Usage for Doxercalciferol Injection

• Doxercalciferol Injection is indicated for the treatment of secondary hyperparathyroidism in adult patients with chronic kidney disease (CKD) on dialysis.

Doxercalciferol Injection Dosage and Administration

Prior to Initiation of Doxercalciferol Injection

• Ensure serum calcium is not above the upper limit of normal before initiating treatment with Doxercalciferol Injection [see Warnings and Precautions (5.1)].

Important Administration Instructions for Doxercalciferol Injection

• Administer Doxercalciferol Injection intravenously as a bolus dose at the end of dialysis.
• Inspect Doxercalciferol Injection visually prior to administration; the solution should appear clear and colorless. Do not use if the solution is not clear or particles are present.
• After initial vial use:
  • discard unused portion of the single-dose vial;
  • store opened multiple-dose vial for up to 3 days at 2°C to 8°C (36°F to 46°F). Discard unused portion of multiple-dose vial after 3 days [see How Supplied/Storage and Handling (16)].

Dosage Recommendations for Doxercalciferol Injection in Patients with CKD on Dialysis

• Initiate Doxercalciferol Injection at a dose of 4 mcg given by bolus intravenous administration three times weekly at the end of dialysis (no more frequently than every other day).
• Target the maintenance dose of Doxercalciferol Injection to intact parathyroid hormone (PTH) levels within the desired therapeutic range and serum calcium within normal limits.
• Monitor serum calcium, phosphorus, and intact PTH levels weekly after initiation of therapy or dose adjustment.
• Titrate the dose of Doxercalciferol Injection based on intact PTH. The dos..