Doxorubicin liposome (Intravenous)
Medically reviewed by Drugs.com. Last updated on Nov 6, 2021.
DOXOrubicin hydrochloride (HCl) liposome injection can cause myocardial damage, including acute left ventricular failure. The risk of cardiomyopathy was 11% when the cumulative anthracycline dose was between 450 to 550 mg/m(2). Assess left ventricular cardiac function prior to initiation of DOXOrubicin HCl liposome and during and after treatment. Serious, life-threatening and fatal infusion-related reactions can occur with DOXOrubicin HCl liposome. Acute infusion-related reactions occurred in 11% of patients with solid tumors. Withhold DOXOrubicin HCl liposome for infusion-related reactions and resume at a reduced rate. Discontinue DOXOrubicin HCl liposome for serious or life-threatening infusion-related reactions .
Commonly used brand name(s)
In the U.S.
- Doxil
- Lipodox
- Lipodox 50
Available Dosage Forms:
- Solution
Therapeutic Class: Antineoplastic Agent
Chemical Class: Anthracycline
Uses for doxorubicin liposome
Doxorubicin liposome injection is used to treat ovarian cancer and Kaposi sarcoma (AIDS patients). It is also used together with bortezomib to treat multiple myeloma. Doxorubicin liposome is an antineoplastic agent (cancer medicine).
Doxorubicin liposome interferes with the growth of cancer cells, which are eventually destroyed by the body. Since the growth of normal body cells may also be affected by doxorubicin liposome, other unwanted side effects will also occur. Some of these may be serious and must be reported to your doctor.
Doxorubicin liposome is to be given only by or under the direct supervision of your doctor.
Before using doxorubicin liposome
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For doxorubicin liposome, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to doxorubicin liposome or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of doxorubicin liposome injection in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of doxorubicin liposome injection in the elderly.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving doxorubicin liposome, it is espe..
