Doxycycline (EENT)

Class: Antibacterials
Chemical Name: 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
Molecular Formula: (C₂₂H₂₄N₂O₈•HCl)₂
CAS Number: 24390-14-5
Brands: Atridox

Medically reviewed by Drugs.com on May 4, 2022. Written by ASHP.

Introduction

Antibacterial; tetracycline antibiotic.

Uses for Doxycycline (EENT)

Periodontitis

Used orally for treatment of adult periodontitis as an adjunct to scaling and root planing to promote attachment-level gain and reduce pocket depth.

Used subgingivally for treatment of chronic adult periodontitis to reduce pocket depth, gain clinical attachment level, and reduce bleeding associated with probing.

Doxycycline (EENT) Dosage and Administration

Administration

Oral Administration

Administered orally as 20-mg tablets for adjunctive treatment of periodontitis.

Take twice daily at least 1 hour prior to or 2 hours after meals.

Give with adequate amounts of fluids to reduce risk of esophageal irritation and ulceration.

Subgingival Administration

Administered subgingivally as an extended-release preparation into periodontal pockets by a dental health-care professional.

Commercially available as a kit containing a syringe of a liquid polymeric delivery system (syringe A), a syringe of doxycycline (syringe B), and a blunt cannula. Contents of the 2 syringes must be mixed together prior to administration. (See Reconstitution under Dosage and Administration.)

Final mixture appears as a pale yellow to yellow viscous liquid; after subgingival administration into periodontal pockets, the liquid solidifies to provide controlled release of doxycycline over a period of 7 days.

Each pair of syringes is intended for single use only.

Administration does not require local anesthesia.

Extended-release preparation i...