Doxycycline (Systemic)

Class: Tetracyclines
VA Class: AM250
CAS Number: 24390-14-5
Brands: Doryx, Doxy 100, Monodox, Vibramycin, Vibra-Tabs

Medically reviewed by Drugs.com on Jun 10, 2022. Written by ASHP.

Introduction

Antibacterial; semisynthetic tetracycline antibiotic derived from oxytetracycline.

Uses for Doxycycline (Systemic)

Respiratory Tract Infections

Treatment of respiratory tract infections caused by Mycoplasma pneumoniae.

Treatment of respiratory tract infections caused by Haemophilus influenzae, Streptococcus pneumoniae, or Klebsiella. Should only be used for treatment of infections caused by these bacteria when in vitro susceptibility tests indicate the organism is susceptible.

Empiric treatment of community-acquired pneumonia (CAP) in conjunction with other anti-infectives. Tetracyclines provide coverage against C. pneumoniae, M. pneumoniae, H. influenzae, and Legionella, but S. pneumoniae may be resistant. Doxycycline is the preferred tetracycline for empiric treatment of CAP.

Alternative for treatment of infections caused by Legionella pneumophila†; used with or without rifampin.

Acne

Adjunctive treatment of moderate to severe inflammatory acne. Not indicated for treatment of noninflammatory acne.

Actinomycosis

Treatment of actinomycosis caused by Actinomyces israelii. Alternative to penicillin G; oral tetracyclines (usually doxycycline or tetracycline) also used as follow-up after initial parenteral penicillin G.

Amebiasis

Adjunct to amebicides for treatment of acute intestinal amebiasis. Tetracyclines not included in current recommendations for treatment of amebiasis caused by Entamoeba.

Anthrax

Postexposure prophylaxis to reduce the incidence or progression of disease following a suspected or confirmed exposure to aerosolized Bacillus anthracis spores (inhalational anthrax). Initial drug of choice for suc...