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Doxylamine and pyridoxine
  • Treatments
  • Nausea/Vomiting of Pregnancy

Doxylamine and pyridoxine

Generic name: doxylamine and pyridoxine [ dox-IL-a-meen-and-PIR-i-DOX-een ]
Brand names: Bonjesta, Diclegis
Dosage forms: oral delayed release tablet (10 mg-10 mg); oral tablet, extended release (20 mg-20 mg)
Drug class:Miscellaneous antiemetics

Medically reviewed by Drugs.com on Aug 24, 2021. Written by Cerner Multum.

What is doxylamine and pyridoxine?

Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body.

Pyridoxine is a form of vitamin B (B6).

Doxylamine and pyridoxine is a combination medicine used to treat nausea and vomiting during pregnancy, sometimes called morning sickness.

Doxylamine and pyridoxine may also be used for purposes not listed in this medication guide.

Warnings

Do not use doxylamine and pyridoxine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Before taking this medicine

Do not use doxylamine and pyridoxine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not use this medicine if you are allergic to doxylamine or pyridoxine, or to other antihistamines such as Benadryl or Dramamine.

Tell your doctor if you have ever had:

  • asthma or other breathing disorder;

  • glaucoma, increased pressure inside your eye;

  • blockage in your digestive tract (stomach or intestines);

  • a stomach ulcer; or

  • bladder obstruction or other urination problems.

You should not breast-feed while using doxylamine and pyridoxine.

Doxylamine and pyridoxine is not approved for use by anyone younger than 18 years old.

How should I take doxylamine and pyridoxine?

Follow all directions on your ...