Dromelate Injection
Generic name: dihydroergotamine mesylate
Dosage form: injection, solution
Drug class:Antimigraine agents
Medically reviewed by Drugs.com. Last updated on Feb 1, 2022.
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Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of DIHYDROERGOTAMINE with potent CYP3A4 inhibitors including protease inhibitors and macrolide antibiotics. Because CYP3A4 inhibition elevates the serum levels of DIHYDROERGOTAMINE, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. Hence, concomitant use of these medications is contraindicated. (See alsoCONTRAINDICATIONSandWARNINGSsections)
Dromelate Injection Description
Dihydroergotamine Mesylate is ergotamine hydrogenated in the 9, 10 position as the mesylate salt. Dihydroergotamine Mesylate is known chemically as ergotaman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-,(5'α)-, monomethanesulfonate. Its molecular weight is 679.80 and its molecular formula is C33H37N5O5•CH4O3S.
The chemical structure is:
Dihydroergotamine Mesylate Injection, USP is a clear, colorless solution supplied in sterile ampules for intravenous, intramuscular, or subcutaneous administration. Each mL contains 1 mg Dihydroergotamine Mesylate, USP; Alcohol, USP 6.1% by volume; Glycerin, USP 15% by weight; Water for Injection, USP; Methanesulfonic Acid and/or Sodium Hydroxide for pH adjustment. pH range is 3.4 - 4.9.
Dromelate Injection - Clinical Pharmacology
Mechanism of Action
Dihydro...
