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Drospirenone and estradiol
  • Treatments
  • Postmenopausal Symptoms

Drospirenone and estradiol

Generic name: drospirenone and estradiol [ droe-SPYE-re-none-and-ES-tra-DYE-ole ]
Brand name: Angeliq
Dosage form: oral tablet (0.25 mg-0.5 mg; 0.5 mg-1 mg)
Drug class:Sex hormone combinations

Medically reviewed by Drugs.com on Aug 27, 2021. Written by Cerner Multum.

What is drospirenone and estradiol?

Drospirenone is a female hormone that helps regulate ovulation and menstruation.

Estradiol is a female hormone involved in development and maintenance of the female reproductive system.

Drospirenone and estradiol is a combination medicine used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. drospirenone and estradiol is for use only if you have a uterus (if you have not had a hysterectomy).

Drospirenone and estradiol may also be used for purposes not listed in this medication guide.

Warnings

You should not use this medicine if you have: undiagnosed vaginal bleeding, coronary artery disease, a bleeding disorder, kidney disease, liver disease, an adrenal gland disorder, if you will have major surgery, if you have had a hysterectomy, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.

Do not use if you are pregnant.

Drospirenone and estradiol may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

Taking this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Drospirenone and estradiol should not be used to prevent heart disease, stroke, or dementia.

Before taking this medicine

You should not use drospirenone and estradiol if you are allergic to drospirenone or estradiol, or if you have:

  • unusual vaginal bleeding that a doctor has not checked;

  • a bleeding disorder;

  • coronary artery disease;

  • a history of heart attack, stroke, or blood clot;

  • kidney disease;

  • liver disease;

  • an adrenal gland disorder;

  • a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina; or

  • if you have had your uterus removed (hysterectomy).

Do not use drospirenone and estradiol if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Taking this medi...