Dyphylline-GG Elixir

Generic name: dyphylline and guaifenesin
Dosage form: elixir
Drug class:Antiasthmatic combinations

Medically reviewed by Drugs.com. Last updated on Nov 22, 2021.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

Dyphylline-GG Elixir Description

DYPHYLLINE-GG is a bronchodilator/expectorant combination available for oral administration as Elixir.

Each 15 mL (one tablespoonful) of Elixir contains:
Dyphylline ..... 100 mg
Guaifenesin ..... 100 mg
Alcohol (by volume) ..... 17 %

Other ingredients: citric acid, FD&C Red No. 40, D&C Yellow No. 10, flavor (artificial), propylene glycol, saccharin sodium, sodium benzoate, sodium citrate, sucrose, water.

Dyphylline is 7-(2,3-dihydroxypropyl)-theophylline, a white, extremely bitter, amorphous powder that is fully soluble in water and soluble in alcohol to the extent of 2 g/100 mL. Dyphylline forms a neutral solution that is stable in gastrointestinal fluids over a wide range of pH.

Dyphylline-GG Elixir - Clinical Pharmacology

Dyphylline is a xanthine derivative with pharmacologic actions similar to theophylline and other members of this class of drugs. Its primary action is that of bronchodilation, but it also exhibits peripheral vasodilatory and other smooth muscle relaxant activity to a lesser degree. The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle.

Dyphylline in Dyphylline-GG Elixir is well tolerated and produces less nausea than aminophylline and other alkaline theophylline compounds when administered orally. Unlike the hydrolyzable salts of theophylline, dyphylline is not converted to free theophylline in vivo. It is absorbed rapidly in therapeutically active form and in healthy volunteers reaches a mean peak plasma concentration of 17.1 mcg/mL in approximately 45 minutes following a single oral dose of 1000 mg of dyphylline.

Dyphylline exerts its bronchodilatory effects directly and, unlike theophylline, is excreted unchanged by the kidneys, without being metabolized by the liver. Because of this,
dyphylline pharmacokinetics and plasma levels are not influenced by various factors that affect liver functio