Ebola Zaire Vaccine Live
Class: Vaccines
Brands: Ervebo
Introduction
Ebola Zaire vaccine live is a live, attenuated virus vaccine that contains replication-competent, recombinant vesicular stomatitis virus (VSV).
Uses for Ebola Zaire Vaccine Live
Ebola Zaire vaccine live has the following uses:
Ebola Zaire vaccine live is indicated for the prevention of Ebola virus disease (EVD) caused by the Zaire ebolavirus species of Ebolavirus in individuals 18 years of age and older.
Ebola Zaire vaccine live has the following limitations of use:
The duration of protection conferred by Ebola Zaire vaccine live is unknown.
Ebola Zaire vaccine live does not protect against other species of Ebolavirus or against Marburgvirus.
Effectiveness of the vaccine when administered concurrently with antiviral medication, immune globulin, and/or blood or plasma transfusions is unknown.
Ebola Zaire Vaccine Live Dosage and Administration
General
Ebola Zaire vaccine live is available in the following dosage form(s) and strength(s):
Suspension, for IM use: Single-dose vial containing one 1-mL dose.
Dosage
It is essential that the manufacturer's labeling be consulted for more detailed information on dosage and administration of this drug. Dosage summary:
Adults
Dosage and Administration
For IM administration only, preferably into the deltoid area of the non-dominant arm.
Administer a single 1-mL dose.
Cautions for Ebola Zaire Vaccine Live
Contraindications
Do not administer to individuals with a history of severe allergic reaction (e.g., anaphylaxis) to any component of Ebola Zaire vaccine live, including rice protein.
Warnings/Precautions
Management of Acute Allergic Reactions
Among 15,399 individuals vaccinated with Ebola Zaire vaccine live, there were two reports of anaphylaxis.
Monitor individuals for signs and symptoms of hypersensitivity reactions following vaccination with Ebola Zaire vaccine live.
Appropriate medical treatment and supervision must be available in case an anaphylactic reaction occurs following administration of the vaccine.
Immunocompromised Individuals
The safety and effectiveness of Ebola Zaire vaccine live have not been assessed in immunocompromised individuals.
The effectiveness of Ebola Zaire vaccine live in immunocompromised individuals may be diminished.
The risk of vaccination with Ebola Zaire vaccine live, a live virus vaccine, in immunocompromised individuals should be weighed against the risk of disease due to Zaire ebolavirus.
Transmission of Vaccine Virus
Because Ebola Zaire vaccine live contains replication-competent, recombinant VSV, transmission of the vaccine virus to close contacts is theoretically possible. Data on the transmissibility of the vaccine virus from the vaccinee to susceptible contacts (humans and animals) are not available to date,
Detection of vaccine virus RNA in vaccinees using reverse t...
