Econazole

Class: Azoles
ATC Class: D01AC03
VA Class: DE102
Chemical Name: (±)-1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole mononitrate
Molecular Formula: C₁₈H₁₅Cl₃N₂OβHNO₃
CAS Number: 68797-31-9

Medically reviewed by Drugs.com on Jun 21, 2021. Written by ASHP.

Introduction

Antifungal; azole (imidazole derivative).

Uses for Econazole

Dermatophytoses

Treatment of tinea corporis (body ringworm) and tinea cruris (jock itch) caused by Epidermophyton floccosum, Microsporum audouinii, M. canis, M. gypseum, Trichophyton mentagrophytes, T. rubrum, or T. tonsurans.

Treatment of tinea pedis (athlete’s foot) caused by E. floccosum, M. audouinii, M. canis, M. gypseum, T. mentagrophytes, T. rubrum, or T. tonsurans.

Topical antifungals usually effective for treatment of uncomplicated tinea corporis or tinea cruris. An oral antifungal may be necessary when tinea corporis or tinea cruris is extensive, dermatophyte folliculitis is present, infection is chronic or does not respond to topical therapy, or patient is immunocompromised because of coexisting disease or concomitant therapy.

Topical antifungals usually effective for treatment of uncomplicated tinea pedis. An oral antifungal may be necessary for treatment of hyperkeratotic areas on the palms and soles, for chronic moccasin-type (dry-type) tinea pedis, and for tinea unguium (fingernail or toenail dermatophyte infections, onychomycosis).

Pityriasis (Tinea) Versicolor

Treatment of pityriasis (tinea) versicolor caused by Malassezia furfur (Pityrosporum orbiculare or P. ovale).

Topical antifungals usually effective; an oral antifungal (with or without a topical antifungal) may be necessary in patients who have extensive or severe infections or have failed to respond to or have frequent relapses with topical therapy.

Cutaneous Candidiasis

Treatment of cutaneous candidiasis caused by Candida albicans.

Econazole Dosage and Administration

Administration

Topical Administration

Apply topically to the skin as a 1% cream.

Do not apply to the eye or administer intravaginally.

Apply a sufficient amount of cream to cover affected areas.

Dosage

Pediatric Patients

Dermatophytoses

Tinea Corporis or Tinea Cruris

Apply once daily for 2 weeks.

If clinical improvement does not occur after treatment, reevaluate diagnosis. Occasionally, a treatment duration of ≥6 weeks may be necessary.

Tinea Pedis

Apply once daily for 1 month.

If clinical improvement does not occur after treatment, reevaluate diagnosis. Occasionally, a treatment duration of ≥6 weeks may be necessary.

Pityriasis (Tinea) Versicolor

Topical

Apply once daily for 2 weeks.

If clinical improvement does not occur after treatment, reevaluate diagnosis.

Cutaneous Candidiasis