Efinaconazole

Class: Azoles
ATC Class: D01AC03
VA Class: DE102
Chemical Name: (αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol
Molecular Formula: C₁₈H₂₂F₂N₄O
CAS Number: 164650-44-6
Brands: Jublia

Medically reviewed by Drugs.com on Feb 3, 2022. Written by ASHP.

Introduction

Antifungal; azole (triazole derivative).

Uses for Efinaconazole

Onychomycosis

Topical treatment of onychomycosis of the toenails (tinea unguium, ringworm of the nail) caused by Trichophyton rubrum or T. mentagrophytes.

Efinaconazole Dosage and Administration

Administration

Topical Administration

Apply 10% solution topically to affected toenails using flow-through brush applicator supplied by the manufacturer.

Do not administer orally or intravaginally; do not apply topically to eyes.

Clean and dry toenails prior to application; do not apply until ≥10 minutes after showering, bathing, or washing.

Using the integrated flow-through brush applicator supplied by the manufacturer on the bottle, place 1 drop of solution on each affected toenail. Use attached brush applicator to gently spread solution evenly over entire toenail surface, including cuticle, folds of skin next to sides of toenail, toenail bed, hyponychium (thickened epidermis underneath toenail tip), and undersurface of toenail tip. For the big toenail, apply second drop at the end of the toenail. Do not squeeze applicator bottle while spreading solution over toenails.

Allow solution to dry on the toenails.

Wash hands with soap and water after applying the drug.

Avoid pedicures and use of nail polish and other cosmetic nail products during efinaconazole treatment.

Dosage

Adults

Onychomycosis

Topical

Apply 10% solution to affected toenails once daily for 48 weeks. Use amount sufficient to cover entire toenail surface and under toenail tip. (See Topical Administration under Dosage and Administration.)

Special Populations

No special population dosage recommendations.

Cautions for Efinaconazole

Contraindications

• Manufacturer states none.

Warnings/Precautions

Sensitivity Reactions

May cause application site irritation (e.g., redness, swelling, burning, itching, blisters); no evidence that the drug causes contact sensitization.

Administration Precautions

For topical use only. Do not use orally or intravaginally; do not apply to ...