Eldepryl Tablets

Generic name:selegiline hydrochloride
Dosage form: tablet
Drug classes:Dopaminergic antiparkinsonism agents, Monoamine oxidase inhibitors

Medically reviewed by Drugs.com. Last updated on Mar 22, 2022.

Eldepryl Tablets Description

ELDEPRYL® (selegiline hydrochloride) is a levorotatory acetylenic derivative of phenethylamine. It is commonly referred to in the clinical and pharmacological literature as l-deprenyl.

The chemical name is: (R)-(-)-N,2-dimethyl-N-2-propynylphenethylamine hydrochloride. It is a white to near white crystalline powder, freely soluble in water, chloroform, and methanol, and has a molecular weight of 223.75. The structural formula is as follows:

Each white, shield-shaped, unscored tablet, debossed on one side with “S” and “5” on the other side. Each tablet contains 5 mg selegiline hydrochloride. Inactive ingredients are anhydrous citric acid, lactose, magnesium stearate, and microcrystalline cellulose.

Eldepryl Tablets - Clinical Pharmacology

The mechanisms accounting for selegiline’s beneficial adjunctive action in the treatment of Parkinson’s disease are not fully understood. Inhibition of monoamine oxidase, type B, activity is generally considered to be of primary importance; in addition, there is evidence that selegiline may act through other mechanisms to increase dopaminergic activity.

Selegiline is best known as an irreversible inhibitor of monoamine oxidase (MAO), an intracellular enzyme associated with the outer membrane of mitochondria. Selegiline inhibits MAO by acting as a ‘suicide’ substrate for the enzyme; that is, it is converted by MAO to an active moiety which combines irreversibly with the active site and/or the enzymes essential FAD cofactor. Because selegiline has greater affinity for type B rather than for type A active sites, it can serve as a selective inhibitor of MAO type B if it is administered at the recommended dose.

MAOs are widely distributed throughout the body; their concentration is especially high in liver, kidney, stomach, intestinal wall, and brain. MAOs are currently subclassified into two types, A and B, which differ in their substrate spe...