Elelyso
Generic name:taliglucerase alfa [ TAL-i-GLOO-ser-ase-AL-fa ]
Drug class:Lysosomal enzymes
What is Elelyso?
Elelyso is a man-made form of an enzyme that occurs naturally in the body. It is used as an enzyme replacement in adults and children at least 4 years old with Type I Gaucher disease.
Gaucher disease is a genetic condition in which the body lacks the enzyme needed to break down certain fatty materials (lipids). Lipids can build up in the body, causing symptoms such as easy bruising or bleeding, weakness, anemia, bone or joint pain, enlarged liver or spleen, or weakened bones that are easily fractured.
Elelyso may improve the condition of the liver, spleen, bones, and blood cells in people with Type I Gaucher disease. However, Elelyso is not a cure for this condition.
Warnings
Some people receiving a Elelyso injection have had a reaction when the medicine was injected, or up to 3 hours later. Tell your caregivers right away if you have a sudden headache, dizziness, warmth or tingling, chest pain, wheezing, nausea, or a red skin rash.
Elelyso is not a cure for Gaucher disease.
Before taking this medicine
You should not use Elelyso if you are allergic to taliglucerase alfa.
Tell your doctor if you are pregnant. It is not known whether taliglucerase alfa will harm an unborn baby. However, having untreated or uncontrolled Type I Gaucher disease during pregnancy may cause new or worsening symptoms in the mother, or complications in the baby such as growth problems or bleeding. The benefit of treating your disease may outweigh any risks to the baby.
It may not be safe to breastfeed while using Elelyso . Ask your doctor about any risk.
How is Elelyso given?
Elelyso is injected into a vein through an IV. A healthcare provider will give you this injection.
You may be given other medications to help prevent an allergic reaction. Keep using these medicines for as long as your doctor has prescribed.
You may be given other medications to prevent certain side effects of Elelyso.
Elelyso is usually given every other week. Follow your doctor's dosing instructions very carefully.
Your doctor may occasionally change your dose to make sure you get the best results.
Taliglucerase alfa doses are based on weight (especially in children and teenagers). Your dose needs may change if you gain or lose weight.
Dosing information
Usual Adult Dose of Elelyso for Gaucher Disease:
Therapy-naive patients: 60 units/kg via IV infusion (administered over 60 to 120 minutes) every other week
Patients switching from imiglucerase:
-Patients currently being treated with imiglucerase for type 1 Gaucher disease can be switched to this drug.
-Patients previously receiving a stable dose of imiglucerase should begin this drug at that same dose when they switch from imiglucerase to talig
