Elexacaftor, ivacaftor, and tezacaftor
Generic name: elexacaftor, ivacaftor, and tezacaftor [ e-LEX-a-KAF-tor, EYE-va-KAF-tor, and-TEXZ-a-KAF-for ]
Brand name: Trikafta
Dosage form: oral tablet (100 mg-75 mg-50 mg and ivacaftor 150 mg; 50 mg-37.5 mg-25 mg and ivacaftor 75 mg)
Drug class:CFTR combinations
What is elexacaftor, ivacaftor, and tezacaftor (Trikafta)?
Trikafta is a combination medicine used to treat cystic fibrosis in adults and children at least 6 years old.
Trikafta is for use only in patients with a specific gene mutation related to cystic fibrosis. You may need a medical test to make sure you have this gene mutation.
Elexacaftor, ivacaftor, and tezacaftor may also be used for purposes not listed in this medication guide.
Warnings
Tell your doctor about all your other medicines. Some drugs should not be used with elexacaftor, ivacaftor, and tezacaftor.
Before taking this medicine
Some drugs should not be used with Trikafta. Your treatment plan may change if you also use:
rifabutin or rifampin;
St. John's wort; or
seizure medicine such as carbamazepine, phenobarbital, or phenytoin.
Tell your doctor if you have ever had:
liver disease; or
kidney disease.
Tell your doctor if you are pregnant or breastfeeding.
How should I take Trikafta?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Trikafta is supplied as two separate daily tablets. The usual dose is 2 orange tablets in the morning and 1 blue tablet in the evening, 12 hours later. Follow your doctor's dosing instructions very carefully.
Swallow the tablet whole and do not crush, chew, or break it.
Doses are based on weight and may change if your child gains or loses weight.
Your dose may change if you also take certain other medications. Your doctor may tell you to take the orange tablets and the blue tablet on separate days. Do not change your dose or dosing schedule without your doctor's advice.
Always take elexacaftor, ivacaftor, and tezacaftor with food that contains fat, such as butter, peanut butter, eggs, nuts, meat, whole milk, cheese, or yogurt. Follow your doctor's dosing instructions very carefully.
You will need frequent blood tests to check your liver function.
A child using this medicine may need frequent eye exams to check for cataracts.
Store at room tempe...
