Elexacaftor, tezacaftor, ivacaftor and ivacaftor (Oral)

Medically reviewed by Drugs.com. Last updated on Mar 29, 2022.

Commonly used brand name(s)

In the U.S.

• Trikafta

Available Dosage Forms:

• Tablet

Uses for elexacaftor, tezacaftor, ivacaftor and ivacaftor

Elexacaftor/tezacaftor/ivacaftor and ivacaftor combination is used to treat cystic fibrosis (CF) in patients who have at least one copy of F508del mutation in their CF transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to elexacaftor, tezacaftor, ivacaftor and ivacaftor. Your doctor will use a test to check for the mutation before you receive the medicine.

Elexacaftor, tezacaftor, ivacaftor and ivacaftor is available only with your doctor's prescription.

Before using elexacaftor, tezacaftor, ivacaftor and ivacaftor

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For elexacaftor, tezacaftor, ivacaftor and ivacaftor, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to elexacaftor, tezacaftor, ivacaftor and ivacaftor or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of Trikafta® in children younger than 6 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies on the relationship of age to the effects of Trikafta® have not been performed in the geriatric population. However, no geriatric-specific problems have been documented to date.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking elexacaftor, tezacaftor, ivacaftor and ivacaftor, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using elexacaftor, tezacaftor, ivacaftor and ivacaftor with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Levoketoconazole

Using elexacaftor, tezacaftor, ivacaftor and ivacaftor with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abametapir
• Alfentanil
• Alprazolam
• Amiodarone
• Apalutamide
• Aprepi...