Enduronyl
Generic name: methyclothiazide and deserpidine
Dosage form: Tablets
Drug class:Antiadrenergic agents (peripheral) with thiazides
Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.
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WARNING:
This fixed combination drug is not indicated for initial therapy of hypertension. Hypertension requires therapy titrated to the individual patient. If the fixed combination represents the dosage so determined, its use may be more convenient in patient management. The treatment of hypertension is not static, but must be reevaluated as conditions in each patient warrant.
Enduronyl Description
Enduronyl tablets are an orally administered combination of Enduron® (methyclothiazide) and deserpidine. Enduronyl tablets are available in two dosage strengths. Enduronyl tablets contain methyclothiazide 5 mg and deserpidine 0.25 mg. Enduronyl FORTE tablets contain methyclothiazide 5 mg and deserpidine 0.5 mg.
Inactive Ingredients
Enduronyl TabletsCorn starch, D&C Yellow No. 10, FD&C Yellow No. 6, lactose, magnesium stearate and talc.
Enduronyl FORTE TabletsCorn starch, iron oxide, lactose, magnesium stearate and talc.
Methyclothiazide is an oral diuretic-antihypertensive of the benzothiadiazine (thiazide) class of drugs. It occurs as a white to practically white crystalline powder which is basically odorless and has a molecular weight of 360.25. Methyclothiazide is very slightly soluble in water and chloroform, and slightly soluble in alcohol. Chemically, methyclothiazide is represented as 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide.
Deserpidine is a purified rauwolfia alkaloid. It occurs as a white to light yellow crystalline powder and has a molecular weight of 578.64. Deserpidine is insoluble in water and very slightly soluble in alcohol. Chemically, deserpidine is identified as 17α-methoxy-18β-[(3,4,5-trimethoxybenzoyl)oxy]-3β,20α-yohimban-16β-carboxylic acid methyl ester. The structural formulas are:
MEDICAL DEPARTMENTS
Cardiology
Pediatrics
Diabetes Care
Pre-natal Care
Ultrasound Echocardiogram
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