Entrectinib
Generic name: entrectinib [ en-TREK-ti-nib ]
Brand name: Rozlytrek
Dosage form: oral capsule (100 mg; 200 mg)
Drug class:Multikinase inhibitors
What is entrectinib?
Entrectinib is used in adults to treat non-small cell lung cancer that has spread to other parts of the body (metastatic).
Entrectinib is also used in adults and children at least 12 years old who have solid tumors that have spread or cannot be safely removed with surgery, or when other treatments have failed or are not safe options.
Entrectinib is used only if your cancer has a specific abnormal gene. Your doctor will test you for this gene.
Entrectinib may also be used for purposes not listed in this medication guide.
Warnings
Entrectinib may cause new or worsened symptoms of congestive heart failure. Call your doctor at once if you have swelling in your lower legs, rapid weight gain, cough, wheezing, shortness of breath, or trouble breathing while lying down.
Before taking this medicine
Tell your doctor if you have ever had:
gout;
heart problems;
long QT syndrome (in you or a family member);
liver or kidney disease;
a nervous system disorder; or
problems with your eyes or vision.
You may need to have a negative pregnancy test before starting this treatment.
Entrectinib can harm an unborn baby or cause birth defects if the mother or the father is using entrectinib.
If you are a woman, do not use entrectinib if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 5 weeks after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using entrectinib.
Do not breastfeed while using this medicine, and for at least 7 days after your last dose.
How should I take entrectinib?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
You may take entrectinib with or without food.
Swallow the capsule whole and do not crush, chew, break, or open it.
If you vomit shortly after taking entrectinib, take another dose.
Store at room temperature away from moisture and heat.
Do not change...
