Estradiol and levonorgestrel (transdermal)
Generic name: estradiol and levonorgestrel (transdermal) [ ess-tra-DY-ol-and-LEE-vo-nor-JESS-trell ]
Brand name: Climara Pro
Dosage form: transdermal film, extended release (0.045 mg-0.015 mg/24 hr)
Drug class:Sex hormone combinations
What are estradiol and levonorgestrel?
Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body. Levonorgestrel is a form of progesterone, a female hormone important for regulating ovulation and menstruation.
Estradiol and levonorgestrel is a combination medicine used to treat menopause symptoms such as hot flashes, and to prevent osteoporosis (bone loss) in menopausal women.
Estradiol and levonorgestrel may also be used for purposes not listed in this medication guide.
Warnings
You should not use estradiol and levonorgestrel if you have had a hysterectomy, or if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.
Do not use if you are pregnant.
Estradiol and levonorgestrel may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.
Using this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Estradiol and levonorgestrel should not be used to prevent heart disease, stroke, or dementia.
Before taking this medicine
You should not use this medicine if you are allergic to estradiol or levonorgestrel, if you have had a hysterectomy, or if you have:
unusual vaginal bleeding that has not been checked by a doctor;
liver disease;
a bleeding disorder;
a history of heart attack, stroke, or blood clot; or
a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.
Do not use estradiol and levonorgestrel if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
Using this medicine can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have
